Role of NF-kB in the Anti-Inflammatory Effects of Tocotrienols

The NF-kB family of transcription factors regulates genes that are critical for inflammation and immunity. In most cells, NF-kB function is induced upon activation of cells by various stimuli. However, constitutive NF-kB activity is an equally important aspect of NF-kB function that is particularly relevant to chronic inflammation and cancer. Here, we provide a brief overview of NF-kB biology and discuss the role of NF-kB in mediating the anti-inflammatory effects of tocotrienols The NF-kB family of transcription factors is a central player in the regulation of inflammation and immune responses. Consequently, NF-kB dysregulation has been implicated in diverse human pathologies ranging from autoimmune diseases to cancers. Additionally, there is considerable interest in the contribution of NF-kB– mediated chronic inflammation in aging. Because NF-kB–dependent gene regulation is important in virtually all mammalian cell types, it is critical to keep in mind some basic features of its functions when considering interventional therapeutics.